A systematic review from 2021 and a meta-analytic approach were considered to investigate the effects of lemon balm as a medicinal herb on anxiety and depression in clinical trials and its side effects. Based on meta-analysis results, lemon balm significantly improved mean anxiety and depression scores compared with the placebo respectively, without serious side effects.
References:
Ghazizadeh, J., Sadigh-Eteghad, S., Marx, W., Fakhari, A., Hamedeyazdan, S., Torbati, M., Taheri-Tarighi, S., Araj-Khodaei, M., & Mirghafourvand, M. (2021). The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta-analysis. Phytotherapy research : PTR, 35(12), 6690–6705. https://doi.org/10.1002/ptr.7252
