This review from 2023 covers the mechanistic evidence for liver benefits of calcium d glucarate specifically glucaric acid. Authors explain four specific molecular pathways: improves liver detoxification by downregulating hepatocyte apoptosis, reducing glucuronide deconjugates levels, reducing ROS production, and inhibiting β-Glucuronidase enzyme that reduces re-absorption of toxins in hepatocytes.
Ayyadurai VAS, Deonikar P, Fields C. Mechanistic Understanding of D-Glucaric Acid to Support Liver Detoxification Essential to Muscle Health Using a Computational Systems Biology Approach. Nutrients. 2023 Feb 1;15(3):733. doi: 10.3390/nu15030733. PMID: 36771439; PMCID: PMC9921405.