This open label, single group allocation study from 2012, included 21 subjects with mild to moderate osteoarthritis. Over eight weeks, subjects were given 3,000 mg/day of GLM extract. After 8 weeks subjects were assessed based on range of motion tests, the WOMAC score, and gastrointestinal scales compared with baseline. Green-lipped mussel significantly improved knee joint pain, stiffness and mobility by 49% in OA patients.
Coulson S, Vecchio P, Gramotnev H, Vitetta L. Green-lipped mussel (Perna canaliculus) extract efficacy in knee osteoarthritis and improvement in gastrointestinal dysfunction: a pilot study. Inflammopharmacology. 2012 Apr;20(2):71-6. doi: 10.1007/s10787-012-0128-6. Epub 2012 Feb 26. PMID: 22366869. https://pubmed.ncbi.nlm.nih.gov/22366869/