A randomized, double-blind, placebo-controlled clinical study from 2021 was conducted in subjects with mild hypertension. It was performed to investigate GSEe benefits on blood pressure regulation. GSEe resulted in a benefit of modulating endothelial functionality and blood pressure. It was noteworthy that GSEe relieved the perceived stress, promising new future perspectives on mood comfort.
Schön, C., Allegrini, P., Engelhart-Jentzsch, K., Riva, A., & Petrangolini, G. (2021). Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers. Nutrients, 13(2), 654. https://doi.org/10.3390/nu13020654