In this systematic review and meta-analysis from 2020, 24 randomized clinical trials (n=1057) aimed to assess the effects of NAC supplementation on inflammatory markers. The anti-inflammatory properties of NAC have been of considerable controversies in the past. NAC is a powerful antioxidant, which can help neutralize free radicals. It also aids in the synthesis of gluthatione (a crucial player in the body’s antioxidant system). Inflammation has been attributed to be the cause of several chronic conditions; metabolic syndrome, DM II, CVD, and several cancers. Oral supplementation of NAC reduced serum level of C-reactive protein (CRP) and interleukin-6 (IL-6). A significant reduction in serum CRP and IL-6 were documented, however it had no significant effects on other inflammatory biomarkers. This warrants further investigation with prospective studies.
Askari, M., Faryabi, R., Mozaffari, H., & Darooghegi Mofrad, M. (2020). The effects of N-Acetylcysteine on serum level of inflammatory biomarkers in adults. Findings from a systematic review and meta-analysis of randomized clinical trials. Cytokine, 135, 155239. https://doi.org/10.1016/j.cyto.2020.155239