Published in 2022, this recent review offers insights into clinical and preclinical evidence of thiamin precursors and their neuroprotective potential. Authors conclude that human clinical research appears promising and requires more support in neurodegenerative diseases and stress-induced anxiety, aggression and depression. With no toxic side-effects reported it is suggested to be a potentially safe and cost-effective treatment for a number of brain diseases.
Sambon, M., Wins, P., & Bettendorff, L. (2021). Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine. International journal of molecular sciences, 22(11), 5418. https://doi.org/10.3390/ijms22115418