In 2022 researchers reviewed the analgesic effects of a number of natural pain remedies including feverfew. Citing evidence of main compounds and composition, historical use as well as emerging clinical use in migraines. Patients using feverfew for up to six months of treatment reported fewer headaches, according to a study involving eight individuals who received feverfew medication and nine placebo-controlled patients.
Kopustinskiene DM, Bernatonyte U, Maslii Y, Herbina N, Bernatoniene J. Natural Herbal Non-Opioid Topical Pain Relievers-Comparison with Traditional Therapy. Pharmaceutics. 2022 Nov 29;14(12):2648. doi: 10.3390/pharmaceutics14122648. PMID: 36559142; PMCID: PMC9785912.