A single-arm pilot study was designed to evaluate the effect of Probiotic-3 against symptoms associated with treatment-refractory ulcerative colitis. Twenty patients with mild to moderate colitis took three Probiotic-3 capsules, three times a day, for four weeks. The primary outcome measure was resolution of symptoms. In total, 45% of patients exhibited complete remission, with 10% showing partial remission. Analysis of their colonic microbiota showed that populations of Bifidobacteria increased significantly in most patients. Furthermore, this positive response was associated with a normalization of intestinal populations of other commensal bacteria.
Tsuda, Y., Yoshimatsu, Y., Aoki, H., Nakamura, K., Irie, M., Fukuda, K., Hosoe, N., Takada, N., Shirai, K., & Suzuki, Y. (2007). Scandinavian journal of gastroenterology, 42(11), 1306–1311. https://doi.org/10.1080/00365520701396091