In this preclinical assessment from 2016, the polyphenol extracts derived from roots of Scutellaria baicalensis and heartwoods of Acacia catechu were investigated to test the effect on memory and learning using a radial arm water maze. The 7 and 34 mg/kg dosage groups had significantly fewer errors than aged vehicle control animals and their performance was equivalent to young animal controls. In a separate human clinical trial, test subjects orally given 300 mg of UP326 BID for 30 days showed marked improvement in speed and accuracy of processing complex information in computer tasks and reduced their standard deviation of performance compared to baseline and the placebo group.
Yimam M, Burnett BP, Brownell L, Jia Q. Clinical and Preclinical Cognitive Function Improvement after Oral Treatment of a Botanical Composition Composed of Extracts from Scutellaria baicalensis and Acacia catechu. Behav Neurol. 2016;2016:7240802. doi: 10.1155/2016/7240802. Epub 2016 Nov 30. Erratum in: Behav Neurol. 2017;2017:3493086. PMID: 28042201; PMCID: PMC5155129.