From 2012, this review looks at the effect of choline on liver function and fatty liver disease. Humans eating low-choline diets develop fatty liver and liver damage. Choline influences liver function, and the dietary requirement for this nutrient varies depending on an individual’s genotype and estrogen status.
Corbin KD, Zeisel SH. Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol. 2012 Mar;28(2):159-65. doi: 10.1097/MOG.0b013e32834e7b4b. PMID: 22134222; PMCID: PMC3601486.