In a randomized, double-blind, placebo-controlled trial, 90 patients with idiopathic chronic fatigue were given 1 g or 2 g of panax ginseng or placebo daily for four weeks. Self-reported mental fatigue scores were significantly improved in the groups given ginseng compared to placebo.
References:
Kim HG, Cho JH, Yoo SR, Lee JS, Han JM, Lee NH, Ahn YC, Son CG. Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial. PLoS One. 2013. 8(4): e61271