In this 2020 published review authors outlined the mechanism of action for anti-inflammatory activity of vinpocetine as the selective inhibitor of phosphodiesterase type 1 (PDE1), with pronounced effect on glial and astrocyte cells during and following ischemic stroke and as an effective adjuvant therapy in the management of epilepsy.
Al-Kuraishy HM, Al-Gareeb AI, Naji MT, Al-Mamorry F. Role of vinpocetine in ischemic stroke and poststroke outcomes: A critical review. Brain Circ. 2020 Feb 18;6(1):1-10. doi: 10.4103/bc.bc_46_19. PMID: 32166194; PMCID: PMC7045535.