In a 2017 randomized placebo-controlled study, 64 patients with type 2 diabetes were given either 500 mg per day of the flavonoid hesperidin or placebo. After six weeks of treatment, researchers measured a significant increase in the total antioxidant capacity in those who were given hesperidin, as well as lowered measures of DNA damage from oxidative stress.
References:
Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Hesperidin supplementation alleviates oxidative DNA damage and lipid peroxidation in type 2 diabetes: a randomized double-blind placebo-controlled clinical tria. Phytother Res. 2017 Oct; 31(10): 1539-45