Advanced cellular health*
- Supports a healthy metabolism
- Helps maintain energy and stamina levels
- Stimulates more than 350 genes that promote healthy cells
$39.97 / month with a 15-day free trial
Out of stock
For many adults, a low-calorie diet is the chosen method for weight management, staying fit, and maintaining health. By definition, a low-calorie diet (also known as ‘caloric restriction’) is when a person limits their daily calorie intake while still getting a sufficient amount of vitamins, minerals, and other important nutrients.
benaGene™ is a supplement that contains oxaloacetate, a substance that helps generate energy without substantially increasing the daily calorie intake. This formula promotes the genes that favor youthful, healthy cells, and is believed to help balance blood sugar. It contains a stabilized form of oxaloacetic acid, which is the world’s first compound to maximize the Krebs’ cycle, the process by which the body uses stored energy. benaGeneTM is a perfect partner for resveratrol supplementation.
benaGene™ increases conversion of the cellular factor of NADH to its oxidized form, NAD. NAD is a niacin-derived coenzyme that is present in all living cells and is critical to the production of adenosine triphosphate (ATP), the body’s source of immediate energy. In short, NAD helps increase cellular energy and stimulates beneficial genes; NADH inhibits them.
Through a process that is similar to intermittent fasting, benaGene™ mimics a low-calorie diet, resulting in up to 98% of the changes in the genetic expression of over 350 genes. By doing so, AOR’s benaGene™ helps to slow down the creation and storage of fat, which in turn promotes vitality and healthy aging.
benaGene™ with thermally stabilized oxaloacetate or 3-carboxy-3-oxopropanoic acid, a key intermediate in the Kreb’s Cycle which is involved in cellular energy production.*
AOR™ guarantees that all ingredients have been declared on the label. Made without wheat, gluten, nuts, peanuts, sesame seeds, sulfites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.
Take one capsule daily with food, or as directed by a qualified health care practitioner.
Do not use if you are pregnant or breastfeeding. Consult a health care practitioner if you have a medical condition, or are taking any medication. Keep out of reach of children. For adult use only. Consult a health care practitioner prior to use if you have diabetes.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
† Daily Value not established.
Other Ingredients: organic rice hull.
Capsule: hypromellose and purified water.
Bhattacharya, R. and R. Tulsawani, In vitro and in vivo evaluation of various carbonyl compounds against cyanide toxicity with particular reference to alpha-ketoglutaric acid. Drug Chem Toxicol, 2008. 31(1): p. 149-61.
Cash A., Modification of the NAD /NADH Ratio Via Oxaloacetic Acid Supplementation to Mimic Calorie Restriction Metabolic Pathways and Increase Lifespan, Anti-Aging Therapeutics Volume XII, American Academy of Anti-Aging Medicine, December 2010.
Cash, A., Oxaloacetic Acid Supplementation as a Mimic of Calorie Restriction. Open Longevity Science, 2009. 3: p. 22-27.
Chang, I., et al., Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes. Diabetologia, 2003. 46(9): p. 1220-7.
Desagher, S., J. Glowinski, and J. Premont, Pyruvate protects neurons against hydrogen peroxide-induced toxicity. J Neurosci, 1997. 17(23): p. 9060-7.
Desagher, S. and J.C. Martinou, Mitochondria as the central control point of apoptosis. Trends Cell Biol, 2000. 10(9): p. 369-77.
Farah, I.O., Differential modulation of intracellular energetics in A549 and MRC-5 cells. Biomed Sci Instrum, 2007. 43: p. 110-5.
Greer, E.L., et al., An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol, 2007. 17(19): p. 1646-56.
Hogan D., et al., (2010) Oxaloacetate Enhances Resistance to Fatigue in In vitro Mouse Soleus Muscle. FACSM Division of Physiology, Department of Medicine, UCSD, La Jolla, CA presented at the American College of Sports Medicine.
Nogueira L., (April 2011) Acute Oxaloacetate Exposure Enhances Resistance to Fatigue in in vitro Mouse Soleus Muscle, Division of Physiology, Department of Medicine, UCSD, La Jolla, CA, The Federation of American Societies for Experimental Biology
O’Donnell-Tormey, J., et al., Secretion of pyruvate. An antioxidant defense of mammalian cells. J Exp Med, 1987. 165(2): p. 500-14.
Puntel, R.L., C.W. Nogueira, and J.B. Rocha, Krebs cycle intermediates modulate thiobarbituric acid reactive species (TBARS) production in rat brain in vitro. Neurochem Res, 2005. 30(2): p. 225-35.
Puntel, R.L., C.W. Nogueira, and J.B. Rocha, N-methyl-D-aspartate receptors are involved in the quinolinic acid, but not in the malonate pro-oxidative activity in vitro. Neurochem Res, 2005. 30(3): p. 417-24.
Williams, D.S., et al., Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell, 2009. 8(6): p. 765-768.
Wood, J.P. and N.N. Osborne, Zinc and energy requirements in induction of oxidative stress to retinal pigmented epithelial cells. Neurochem Res, 2003. 28(10): p. 1525-33.
Yoshikawa, K., Studies on the anti-diabetic effect of sodium oxaloacetate. Tohoku J Exp Med, 1968. 96(2): p. 127-41.
Yamamoto, H.A. and P.V. Mohanan, Effect of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice. Toxicol Lett, 2003. 143(2): p. 115-22.
Zlotnik, A., et al., Brain neuroprotection by scavenging blood glutamate. Exp Neurol, 2007. 203(1): p. 213-20.