Curcumin is the active compound in turmeric, which is a tuberose rhizome that is part of the ginger family. Turmeric root is traditionally grown in India, where it has been used for centuries to treat a broad range of illnesses. It’s also a common ingredient in Indian cuisine. The beautiful hue of turmeric is but a hint of the bounty of benefits that lie within its cellular makeup. Curcumin Acts as a Natural Anti-Inflammatory Chronic inflammation is a condition that keeps the body in a constant state of stress. It’s brought about by many factors including poor diet, lack of
In more recent years, the anti-carcinogenic activity of curcumin both in prevention and treatment has been studied in colon, bone marrow, breast (Liu et al., 2013), prostate, and lung cancer (Sharma et al., 2001; Gomez-Bougie et al., 2015; Tieten et al., 2010; Tsai et al., 2015). While curcumin has been established as safe and nontoxic at high doses in humans (Krishnakumar et al., 2015), how curcumin has such a diverse range of medicinal effects is less understood.
The liver is the major organ responsible for metabolizing or breaking down substances. When something is ingested, it is normally absorbed into the bloodstream through the hepatic portal vein. The first stop for this “portal blood” is the liver. Here, these substances have phase II enzyme groups known as glucuronide or sulphate added to them. This process is known as conjugation or biotransformation (hepatic first pass metabolism) and makes a substance extremely soluble. These newly formed metabolites are then carried to our kidneys and bowel and ready for excretion.
When curcumin is able to avoid this rapid breakdown, it retains its activity. Furthermore, a true understanding of free form curcumin clarifies how bioavailability and absorbability are only one side of a very complex coin when it comes to curcumin. When the whole picture is in view, we are able to gain clarity into the present state of curcumin within our industry. What you might believe is a high quality, effective product, might not be, and products with superior formulation are often highly misunderstood. However, once the process of biotransformation is better understood, it becomes clear that all of curcumin’s benefits significantly increase when it retains its free form. Thus, resulting in a highly potent, bioactive product.