PEA: Unique topical health benefits
The skin is one of the largest organs in the body and has a variety of cells including: keratinocytes, sebaceous glands, fibroblasts, melanocytes, adipocytes (fat cells) and so on. These cells in turn have a large range of receptors among others, endocannabinoid and related receptors like CB1, CB2, TRPV1, PPAR, COX, opioid, TLR, GRP55, GPR119 etc. Observational reports from the 1990s showed that when cannabis, hashish and other variants of cannabis were abused, there was accompanied skin disorders like hair loss, acne, ageing, dermatitis, dry skin etc. These observations indicated that cannabinoids may modulate these receptors and that using the